Article Text


ASCO: practice changing studies in gastrointestinal cancer
  1. Gerald Prager
  1. Department of Medicine, Comprehensive Cancer Center, Medical University Vienna, Austria, Vienna, Austria
  1. Correspondence to Dr Gerald Prager; gerald.prager{at}
  • gastrointestinal cancer

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:

Statistics from

In this podcast, new, practice-changing research in gastrointestinal (GI) cancer is considered. Clinical trials focusing on immunotherapies presented at the recent American Society of Clinical Oncology Gastrointestinal Cancers Symposium in San Francisco are discussed. Highlights included reports of the ONO-4538 study, in which pretreated patients with gastric cancer were randomised to receive either nivolumab or best supportive care, and of the CheckMate 040 study, in which pretreated patients with hepatocellular carcinoma received nivolumab. Nivolumab was also assessed in the CheckMate 142, which considered patients with DNA mismatch repair deficient/microsatellite instability high metastatic colorectal cancer. Other new treatment options and combinations with immunotherapy are briefly considered, but the author suggests that it is too early to draw conclusions from these preliminary data. Emergent side effects from immunotherapy trials in GI cancer are also discussed. In closing, the author considers developments in immunotherapy of GI cancers in the adjuvant setting but notes that trial results are still awaited.

View Abstract


  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.