Table 1

Relationship between HER2 copy number and HER2 IHC scores for cases of invasive breast carcinoma, stratified by HER2 wild-type/mutant status

Shallow deletionDiploidLow-level copy number gainHigh-level amplification
IHC 022 (0 mutant)26 (1 mutant)10 (0 mutant)2 (0 mutant)
IHC 165 (0 mutant)119 (4 mutant)53 (3 mutant)6 (0 mutant)
IHC 224 (0 mutant)75 (0 mutant)51 (3 mutant)25 (1 mutant)
IHC 34 (0 mutant)8 (0 mutant)7 (0 mutant)59 (1 mutant)
  • As perĀ figure 1, this was derived from provisional TCGA data from sequencing and expression analyses of invasive breast carcinoma cases, where all required data for this analysis was available. Data were derived from cbioportal.org.

  • IHC, immunohistochemistry; TCGA, The Cancer Genome Atlas.