Table 2

Sequential evaluations of renal function

Conventional hydrationShort hydration
Before treatmentAfter first cycleAfter last cycleBefore treatmentAfter first cycleAfter last cycle
Creatinine elevation* (n, %)
 Grade 0344 (96.6)308 (86.5)238 (66.9)107 (96.4)107 (96.4)95 (85.6)
 Grade 112 (3.4)45 (12.6)103 (28.9)4 (3.6)4 (3.6)16 (14.4)
 Grade 2* 0 (0)3 (0.9)15 (4.2)0 (0)0 (0)0 (0)
Serum creatinine (mg/dL)
 Median0.70.760.800.70.750.79
 Range0.37–1.30.37–2.50.37–2.50.4–1.10.4–1.30.4–1.6
Ccr† (mL/min)
 Median92.483.673.293.187.282.1
 Range44.2–253.730.3–240.627.0–216.949.4–173.242.9–153.238.1–176.1
eGFR‡ (mL/min/1.73 m2)
 Median85.076.065.380.877.573.7
 Range43.4–198.322.2–167.422.2–167.453.0–126.144.1–141.736.9–141.7
  • *Maximum grade of creatinine elevation according to the National Cancer Institute Common Toxicity Criteria (CTCAE), V.4.0.

  • †Calculated creatinine clearance using the Cockcroft-Gault equation, mL/min.

  • ‡eGFR using the Japanese equations for estimating the glomerular filtration rate from the serum Cr level, mL/min/1.73 m2.

  • Ccr, creatinine clearance; eGFR, estimated glomerular filtration rate.