Table 1

Reported gene fusions involving NTRK genes along with the corresponding tumour

Gene fusionCancer typeAuthors (year)
NTRK1
LMNA-NTRK1ColorectalSartore-Bianchi et al (2016)
Soft tissue sarcomaDoebele et al (2015)
Spitzoid melanomasWiesner et al (2014)
AYA sarcomaMorosini et al (2015)
Congenital infantile fibrosarcomaWong et al (2015)
TPM3-NTRK1ColorectalLee et al (2015), Créancier et al (2015), Ardini et al (2014)
Papillary thyroid carcinomasBongarzone et al (1989), Butti et al (1995)
GlioblastomaWu et al (2014)
SQSTM1-NTRK1NSCLCFarago et al (2015)
NTRK1-SQSTM1NSCLCSiena et al (2015)
NFASC-NTRK1Glioblastoma multiformeFrattini et al (2013), Kim et al (2014)
BCAN-NTRK1Glioblastoma multiformeKim et al (2014), Frattini et al (2013)
PPL-NTRK1Thyroid carcinomaFarago et al (2015)
RFWD2-NTRK1Large cell neuroendocrine tumour (lung)Fernandez-Cuesta et al (2014)
CD74-NTRK1Lung adenocarcinomasVaishnavi et al (2013)
MPRIP-NTRK1Lung adenocarcinomasVaishnavi et al (2013)
RABGAP1L-NTRK1ICCRoss et al (2014)
TFG-NTRK1Thyroid carcinomasGreco et al (1995)
TP53-NTRK1Spitzoid melanomasWiesner et al (2014)
NTRK2
Unknown-NTRK1Appendiceal adenocarcinomaBraghiroli et al (2016)
AFAP1-NTRK2Low-grade gliomaStransky et al (2014)
AGBL4-NTRK2GlioblastomaWu et al (2014)
NACC2-NTRK2Pilocytic astrocytomasJones et al (2013)
PAN3-NTRK2Head and neck squamous cell carcinomaWu et al (2014)
QKI-NTRK2Pilocytic astrocytomasJones et al (2013)
TRIM24-NTRK2Lung adenocarcinomaWu et al (2014)
VCL-NTRK2GlioblastomaWu et al (2014)
NTRK3
ETV6-NTRK3GlioblastomaZhang et al (2013)
GlioblastomaWu et al (2014)
MASCTognon et al (2002), Ito et al (2015), Del Castillo et al (2015)
Ductal carcinomaMakretsov et al (2004), Arce et al (2005), Lagree et al (2011), Pinto et al (2014)
FibrosarcomaMorerio et al (2004), Punnett et al (2000)
Congenital mesoblastic nephromaWatanabe et al (2002)
Radiation-associated thyroid cancerLeeman-Neill et al (2014)
AMLKralik et al (2011), Eguchi et al (1999), Knezevich et al (1998)
GISTBrenca et al (2015)
MASC of salivary glandUrano et al (2015), Skàlovà et al (2015)
Papillary thyroid cancerLeeman-Neill et al (2014), Seungbok Lee et al (2014)
ColorectalHechtman et al (2015)
BTBD1-NTRK3GlioblastomaWu et al (2014)
  • AFAP1, actin filament-associated protein 1; AGBL4, ATP/GTP-binding protein-like 4; AML, acute myeloid leukaemia; AYA, adolescents and young adults; BCAN, brevican; BTBD1, BTB (POZ) domain containing 1; CD74, CD74 molecule; ETV6, ets variant 6; GIST, gastrointestinal stromal tumor; ICC, intrahepatic cholangiocarcinoma; LMNA, lamin A/C; MASC, mammary secretory breast carcinoma; MPRIP, myosin phosphatase Rho interacting protein; NACC2, NACC family member 2, BEN and BTB (POZ) domain containing; NFASC, neurofascin; NSCLC, non-small cell lung cancer; PAN3, PAN3 poly(A) specific ribonuclease subunit; PPL, periplakin; QKI, KH domain containing RNA binding; RABGAP1L, RAB GTPase activating protein 1-like; RFWD2, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; SQSTM1, sequestosome 1; TFG, TRK-fused gene; TP53, tumour protein p53; TPM3, tropomyosin 3; TRIM24, tripartite motif containing 24; VCL, vinculin.