Objectives
  • To be able to handle the first diagnosis of a patient with gastrointestinal stromal tumour (GIST) and to proactively refer patients with GIST to sarcoma reference centres for specialised multidisciplinary treatment

  • To be able to collaborate with a sarcoma reference centre in medical management of patients with GIST, if needed, through active clinical networking

Awareness
  • Awareness that GIST are rare cancers, worth being referred to centres specialised in their treatment

  • Recognition that GIST can be first diagnosed on an emergency basis

  • Recognition that GIST should be considered during the differential diagnosis of abdominal masses and may be diagnosed as incidental endoscopic findings

  • Appreciation that proper treatment should be selected on a multidisciplinary basis

  • Appreciation that molecular targeted agents are especially effective and used in the adjuvant and in the advanced disease settings, with specific issues pertaining to side effects and tumour response assessment

Knowledge
  • Knowledge of the main concepts regarding the following aspects of GIST:

    • Essentials of natural history of disease, including the existence of so-called wild-type GIST, in addition to the typical cKIT/platelet-derived growth factor receptor A (PDGFRA)-mutated GIST

    • Importance of genotyping and existence of prognostic classifications

    • Objectives of surgery for localised disease

    • Potential of adjuvant molecular targeted therapy

    • Gross biological rationale of molecular targeted therapies

    • Principles of systemic treatment with molecular targeted agents approved for use in GIST

    • Patterns of non-dimensional tumour response to molecular targeted agents

Skills
  • Ability to advise surgeons and gastroenterologists facing a clinical/pathological diagnosis of GIST or suspected GIST

  • Ability to refer patients with GIST to centres of reference by collecting and conveying essential, meaningful clinical information

  • Ability to actively discuss patient cases with reference centres in regard to strategic clinical decisions and medical treatment conduct, as needed