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Cancer and liver cirrhosis: implications on prognosis and management
  1. Matthias Pinter1,2,
  2. Michael Trauner1,
  3. Markus Peck-Radosavljevic1,3,
  4. Wolfgang Sieghart1,4
  1. 1Division of Gastroenterology & Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
  2. 2Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Harvard Medical School & Massachusetts General Hospital, Boston, USA
  3. 3Department of Gastroenterology & Hepatology, Endocrinology and Nephrology, Klinikum Klagenfurt am Wörthersee, Klagenfurt, Austria
  4. 4Austrian Society of Gastroenterology & Hepatology, Working Group GI-Oncology
  1. Correspondence to Dr Wolfgang Sieghart; wolfgang.sieghart{at}


Liver cirrhosis, the end-stage of every chronic liver disease, is not only the major risk factor for the development of hepatocellular carcinoma but also a limiting factor for anticancer therapy of liver and non-hepatic malignancies. Liver cirrhosis may limit surgical and interventional approaches to cancer treatment, influence pharmacokinetics of anticancer drugs, increase side effects of chemotherapy, render patients susceptible for hepatotoxicity, and ultimately result in a competitive risk for morbidity and mortality. In this review, we provide a concise overview about the impact of liver cirrhosis on the management and prognosis of patients with primary liver cancer or non-hepatic malignancies.

  • hepatocellular carcinoma
  • intrahepatic cholangiocarcinoma
  • non-hepatic cancer
  • liver cirrhosis
  • viral reactivation

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