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Targeting immune checkpoints in breast cancer: an update of early results
  1. Cinzia Solinas1,
  2. Andrea Gombos2,
  3. Sofiya Latifyan2,
  4. Martine Piccart-Gebhart2,
  5. Marleen Kok3,
  6. Laurence Buisseret1,2,4
  1. 1Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium
  2. 2Department of Medicine, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium
  3. 3Department of Medical Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  4. 4Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium
  1. Correspondence to Dr Cinzia Solinas; cinzia.solinas{at}bordet.be and Dr Laurence Buisseret; laurence.buisseret{at}bordet.be

Abstract

The immune tumour microenvironment has been shown to play a crucial role in the development and progression of cancer. Expression of gene signatures, reflecting immune activation, and the presence of tumour-infiltrating lymphocytes were associated with favourable outcomes in HER2-positive and triple-negative breast cancer. Recently, immunotherapy with immune checkpoint blockade induced long-lasting responses and improved survival in hard-to-treat malignancies (ie, melanoma and non-small cell lung cancer) and are changing treatment paradigms in a variety of neoplastic diseases. Immune checkpoint blockade has been evaluated in breast cancer, particularly in the triple-negative subtype, with promising results observed in monotherapy or in combination with chemotherapy in the metastatic and neoadjuvant settings. However, identification of patients who are most likely to benefit from immune checkpoint blockade remains challenging, with many patients not responding to treatments and a significant financial cost. The combination of immune checkpoint blockade with conventional cancer treatments such as chemotherapy, radiotherapy, targeted therapies or with other immunotherapies is a promising strategy to potentiate its efficacy in breast cancer although further research is required to effectively identify who will respond to these immunotherapies. In this review we report the most recent results that emerged from trials testing immune checkpoint blockade and potential predictive biomarkers and emphasise the new strategies that are under clinical development in breast cancer.

  • immunotherapy, breast cancer, anti-PD-1, anti-PD-L1, immune checkpoint blockade, PD-L1

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Footnotes

  • Contributors CS, AG, SL, MK and LB did the bibliographic research and took responsibility for the data accuracy. MP-G provided critical revision of the work. CS, MK and LB drafted and led on the writing of the manuscript. All the other authors participated in the interpretation of the data, revised the manuscript critically for important intellectual content and redrafted some of its sections. All the authors read and approved the final version of the manuscript and agreed to be accountable for all aspects of the work to ensure its accuracy and integrity. LB coordinated and supervised the whole process and gave final approval for manuscript submission.

  • Competing interests None declared.

  • Patient consent Detail has been removed from this case description/these case descriptions to ensure anonymity. The editors and reviewers have seen the detailed information available and are satisfied that the information backs up the case the authors are making.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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