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Short description of the clinical case
A 68-year-old man is being treated with cisplatin-pemetrexed in the first line for bone metastatic lung adenocarcinoma. There is partial response and very good tolerance with no grade 3–4 toxicities. After six cycles of doublet therapy, the patient follows on pemetrexed maintenance. Six months later, he develops a hot and itchy rash with poor response to corticoids and topical antibiotics.
Quiz option A: Skin toxicity to cisplatin
Quiz option B: Skin toxicity to pemetrexed
Quiz option C: Erysipelas
Quiz option D: Carcinoma erysipeloides
Quiz option E: Inflammatory breast cancer
Quiz option F: Cellulitis
D: Carcinoma erysipeloides
Carcinoma erysipeloides is a rare entity in cutaneous metastases that mingles with skin infections such as cellulitis or lymphangitis. It should be suspected in cutaneous inflammatory conditions with poor response to corticoids and topical antibiotics such as the case presented. A punch biopsy was performed resulting in dermal lymphatic infiltration by adenocarcinoma of probably pulmonary origin giving the diagnosis of carcinoma erysipeloides as progression of the disease. It was decided to switch to a second-line treatment with docetaxel-nintedanib with stable disease and relieving skin symptoms.
Competing interests None declared.
Patient consent Obtained.
Provenance and peer review Not commissioned; internally peer reviewed.
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