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Brain metastases are a particular problem of melanoma patients, as this complication occurs early and frequently. Further, brain metastases are associated with a high symptom burden and are often the cause of death in advanced melanoma. Recently, systemic treatment approaches including immunotherapy and tyrosine kinase inhibitors have become increasingly important in the management of melanoma brain metastases patients. Indeed, some patients with small, asymptomatic brain metastases without oedema or need for steroid treatment might be candidates for a primarily systemic treatment with very close surveillance for progression or new metastases in the brain requiring focused radiotherapy. Professor Margolin discusses in the present podcast the different treatment strategies as well as the clinical challenge of handling melanoma patients with brain metastases.
Funding The author has not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; internally peer reviewed.
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