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The therapeutic landscape in melanoma is evolving rapidly. In this podcast, Dr Jonathan Lim (a member of the ESMO Young Oncologists Committee) interviews Dr Teresa Amaral (the current chair of the ESMO Young Oncologists Committee and an expert in melanoma) for an update on the current practice and advances in adjuvant and neoadjuvant therapies in melanoma.
Dr Amaral summarises key practice-changing studies which have established the current recommendations in this field, including CheckMate 238, KEYNOTE 054, COMBI-AD, Combi-Neo, NeoCombi and opACIN-neo. We also deliberated on the toxicity profile of these therapies, and currently available evidence of neoadjuvant versus adjuvant therapies. Finally, we addressed how COVID-19 has affected the delivery of adjuvant and neoadjuvant therapies in patients with melanoma.
CheckMate 238 – https://doi.org/10.1056/NEJMoa1709030
KEYNOTE 054 – https://doi.org/10.1056/NEJMoa1802357
EORTC18071 – https://doi.org/10.1016/S1470-2045(15)70122-1
Mixture-Cure Modelling in CheckMate 238 – https://doi.org/10.1093/annonc/mdz255
COMBI-AD – https://doi.org/10.1056/NEJMoa1708539
Combi-Neo – https://doi.org/10.1016/S1470-2045(18)30015-9
OpACIN-neo – https://doi.org/10.1016/S1470-2045(19)30151-2
Funding The authors have not declared a specific grant for this particular research from any funding agency in the public, commercial or not-for-profit sectors. KHJL is currently funded by the Wellcome Imperial 4i Clinical Research Fellowship.
Competing interests TA receives personal fees and travel support from Bristol-Myers Squibb and Novartis, and personal fees from Pierre Fabre and CeCaVa.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; internally peer reviewed.
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