Table 2

All grade adverse events in both arms. Only the worst grade toxicity is shown

VariablePemetrexed arm (n=141)Gefitinib arm (n=145)
Haematological
Anaemia111 (78.7%) 77 (53.1%)
Neutropaenia 53 (37.6%) 4 (2.8%)
Thrombocytopaenia 57 (40.4%) 10 (6.9%)
Biochemical
Raised SGOT 57 (40.4%) 77 (53.1%)
Raised SGPT 72 (51.1%) 79 (54.5%)
Clinical
Skin rash 40 (28.4%)101 (69.7%)
Loose motions 39 (27.7%) 67 (46.2%)
Vomiting 34 (24.1%) 19 (13.1%)
Febrile neutropaenia 12 (8.5%)  1 (0.7%)
  • SGOT, serum glutamic oxaloacetic transaminase; SGPT, serum glutamic aspartate aminotransferase.