Table 2

Efficacy results (as-treated population*)

 ParameterCentral ALK-testing (n=908)Local ALK-testing (n=158)
Result95% CIResult95% CI
BOR, n (%)
 CR11 (1)1 (<1)
 PR
480 (53)63 (40)
 ORR, n (%)
491 (54)51 to 57 64 (41)33 to 49
Median DR, months11.810.4 to 12.8 9.56.9 to 15.2
DCR, n (%)
  At 6 weeks742 (82)79 to 84 110 (70)62 to 77
  At 12 weeks643 (71)68 to 74 97 (61)53 to 69
Median time to first tumour response, weeks6.12.7 to 164§ 6.34.7 to 65.9§
Median PFS, months8.47.1 to 9.7 6.95.6 to 9.4
Survival probability, %
  At 6 months8279 to 84 7870 to 8§¶
  At 12 months6763 to 70 6254 to 60
Median OS, months21.819.4 to 24.0 16.913.4 to 21.5