Table 3

Univariate Cox regression analysis for overall survival (OS) from the first dose of intrathecal interleukin-2 (IL-2) for on-treatment characteristics

VariableLevelTotal NTotal deathsMedian OSHR95% CIP value
Total IL-2 doses received during Induction
 Per dose43357.80.890.77 to 1.010.08
Dose reduction
 No241811.8
 Yes19175.11.730.88 to 3.410.11
CSF positive at baseline (N = 30): CSF clearing
 No20194.5
 Yes989.30.980.42 to 2.290.96
 Missing11****
CSF negative at baseline (N = 13): cytology conversion to positive
 No73
 Yes6416.22.310.51 to 10.440.28
  • *Not available.

  • CSF, cerebrospinal fluid.