Table 3

Impact of low creatinine clearance (≤50) on AEs ≥grade 3 due to oxaliplatin-containing adjuvant chemotherapy

OR95% CIP value
FOLFOX
 Treatment duration (3 vs 6 months)0.560.36 to 0.890.014
 Age (/10 years)1.180.92 to 1.510.20
 CCr (≤50 vs >50)1.490.63 to 3.570.36
CAPOX
 Treatment duration (3 vs 6 months)0.520.40 to 0.68<0.001
 Age (/10 years)1.040.89 to 1.20.64
 CCr (≤50 vs >50)1.671.01 to 2.780.048
  • AE, adverse event; CCr, creatinine clearance.