Table 1

Characteristics of the patients

n (%)Arm 6Arm 3
mFOLFOX6CAPOXmFOLFOX6CAPOX
n=158n=477n=161n=481
Sex
 Male80 (51)237 (50)77 (48)249 (52)
 Female78(49)240(50)84(52)232(48)
Age (years)
 Median67.5656965
 Range 34–82 28–85 31–85 29–83
ECOG PS
 0154 (97.5)462 (97)154 (96)461 (96)
 14 (2.5)15 (3)7 (4)20 (4)
CCr (mL/min)
 ≤5013 (8)34 (7)11 (7)31 (6)
 >50145 (92)443 (93)150 (93)450 (94)
BSA (m2)
 ≤1.4548 (30)118 (25)39 (24)114 (24)
 1.45–1.7068 (43)255 (54)83 (52)231 (48)
 >1.7042 (27)104 (22)39 (24)136 (28)
Tumour site
 Colon117 (74)367 (77)121 (75)370 (77)
 Rectosigmoid40 (25)95 (20)35 (22)99 (21)
 Multiple1 (1)15 (3)5 (3)12 (3)
pT*
 T1–221 (13)69 (14.5)16 (10)84 (17.5)
 T3–4137 (87)408 (85.5)145 (90)397 (82.5)
pN*
 N1113 (71.5)357 (75)118 (73)359 (75)
 N2–345 (28.5)120 (25)43 (27)122 (25)
  • *International Union Against Cancer (UICC) tumour–node–metastasis classification, 7th ed.

  • BSA, body surface area; CCr, creatinine clearance calculated by the formula of Cockroft and Gault; ECOG PS, Eastern Cooperative Oncology Group performance status.