Table 3

Univariate and multivariate analyses with respect to overall survival in breast cancer subtypes

Univariate analysisMultivariate analysis
HR95% CIP valuesHR95% CIP values
All breast cancer (n=129)
 Age (≤56 years)1.7000.733 to 4.1240.217
 Tumour size (>2 cm)1.4210.415 to 8.9010.619
 Lymph node (+)2.2800.776 to 9.7100.145
 Ki-67 (>14)1.2720.547 to 3.0920.578
 Subtype (TNBC)2.9331.186 to 7.5860.0204.0241.395 to 12.5220.010
 Pathological response (non-PR)13.7715.397 to 35.763<0.00115.5645.368 to 48.819<0.001
 TIL (%) change (low)1.3160.568 to 3.1910.524
 CD8 change (low)3.1031.147 to 10.7970.0242.2710.769 to 8.3520.143
 FOXP3 change (high)2.5861.086 to 6.2300.0320.7730.262 to 2.3250.640
 CFR change (low)8.2792.800 to 35.365<0.0017.1771.921 to 34.6870.003
TNBC (n=39)
 Age (≤56 years)2.2640.674 to 8.7560.187
 Tumour size (>2 cm)0.3490.089 to 2.3030.232
 Lymph node (+)0.7980.229 to 3.6540.744
 Ki-67 (>14)1.6480.475 to 7.5420.446
 Pathological response (non-PR)11.8120.043 to 23.141<0.00111.24320.791 to 20.892<0.001
 TIL (%) change (low)1.2700.380 to 4.4310.694
 CD8 change (low)1.8220.525 to 8.3400.358
 FOXP3 change (high)3.3240.949 to 15.3110.061
 CFR change (low)9.8471.883 to 180.7640.0048.3461.538 to 155.1280.010
HRBC (n=77)
 Age (≤56 years)1.8760.460 to 9.1550.381
 Tumour size (>2 cm)6.4740.716 to 0.7160.092
 Lymph node (+)7.6401.184 to 16.8520.0356.5481.037 to 1.0830.047
 Ki-67 (>14)0.9550.225 to 4.0540.948
 Pathological response (non-PR)3.2350.473 to 14.0850.198
 TIL (%) change (low)1.3690.336 to 6.6780.664
 CD8 change (low)5.2830.939 to 98.7830.060
 FOXP3 change (high)2.2310.455 to 9.1590.295
 CFR change (low)11.0811.969 to 207.3230.00410.3331.832 to 193.3360.006
  • Values in parentheses are 95% CIs.

  • CFR, CD8/FOXP3 ratio; FOXP3, forkhead box protein; HRBC, hormone receptor-positive breast cancer; PR, partial response; TIL, tumour-infiltrating lymphocyte; TNBC, triple-negative breast cancer.