Table 2

Univariate and multivariate analyses with respect to recurrence-free survival in breast cancer subtypes

Univariate analysisMultivariate analysis
HR95% CIP valuesHR95% CIP values
All breast cancer (n=129)
 Age (≤56 years)1.4060.729 to 2.7550.309
 Tumour size (>2 cm)1.0980.434 to 3.6930.859
 Lymph node (+)2.0040.895 to 5.3420.095
 Ki-67 (>14)1.0120.523 to 1.9740.971
 Subtype (TNBC)1.4940.553 to 4.7060.441
 Pathological response (non-PR)6.3272.893 to 13.133<0.0015.2602.373 to 11.145<0.001
 TIL (%) change (low)1.2760.656 to 2.5360.473
 CD8 change (low)3.1141.430 to 7.7730.0032.3041.052 to 5.7760.036
 FOXP3 change (high)1.9780.996 to 3.8940.051
 CFR change (low)5.6122.581 to 14.001<0.0014.6632.133 to 11.682<0.001
TNBC (n=39)
 Age (≤56 years)1.5470.491 to 5.2520.455
 Tumour size (>2 cm)0.2610.066 to 1.7210.139
 Lymph node (+)0.9340.279 to 4.2120.919
 Ki-67 (>14)1.1380.358 to 4.2640.832
 Pathological response (non-PR)25.6426.873 to 123.724<0.00134.2907.314 to 265.738<0.001
 TIL (%) change (low)1.7010.542 to 5.7580.361
 CD8 change (low)2.3390.697 to 10.5510.177
 FOXP3 change (high)2.1060.660 to 7.9220.212
 CFR change (low)11.4202.215 to 208.7420.00213.0212.241 to 258.1360.002
HRBC (n=77)
 Age (≤56 years)1.1820.475 to 2.9820.717
 Tumour size (>2 cm)3.6220.743 to 65.2480.128
 Lymph node (+)2.8030.796 to 17.7490.118
 Ki-67 (>14)0.7810.305 to 1.9690.597
 Pathological response (non-PR)2.1320.488 to 6.6250.277
 TIL (%) change (low)1.0690.404 to 2.8850.892
 CD8 change (low)3.1671.134 to 11.1960.0272.7460.976 to 9.7410.056
 FOXP3 change (high)1.9850.682 to 5.2370.196
 CFR change (low)4.7401.779 to 14.8330.0024.3771.641 to 13.7120.003
  • Values in parentheses are 95% CIs.

  • CFR, CD8/FOXP3 ratio; FOXP3, forkhead box protein; HRBC, hormone receptor-positive breast cancer; PR, partial response; TIL, tumour-infiltrating lymphocyte; TNBC, triple-negative breast cancer.