Table 3

Na18F PET response criteria in primary bone tumours (NAFCIST)*

Response categoryCriteria
Complete metabolic responseNormalisation of all lesions (target and non-target) to SUV less than the mean skeletal SUV and equal to the normal surrounding tissue SUV; verification with follow-up study in 1 month if anatomical criteria indicate disease progression.
Partial metabolic response>30% decrease in SUV peak*; verification with follow-up study if anatomical criteria indicate disease progression.
Progressive metabolic disease>30% increase in SUV peak*; >75% increase in total Na18F burden of the five most active lesions; visible increase in the extent of Na18F uptake; new lesions; verification with follow-up study if anatomical criteria indicate complete or partial response.
Stable metabolic diseaseDoes not meet other criteria.
  • *Primary outcome determination is measured on the single most active lesion on each scan (not necessarily the same lesion). Secondary outcome determination is the summed activity of up to the five most intense lesions (no more than two lesions per organ).

  • NAFCIST, Na18F PET response Criteria in Solid Tumors; Na18F, sodium fluoride-18; SUV, standardised uptake value.