Table 1

Baseline characteristics

CharacteristicsOverall population
N=225
N (%)
Never resected
N=61
N (%)
At least one liver treatment
N=164
N (%)
P value*
Age (years) 0.04
 ≥7038 (15)16 (26)22 (13)
 <70187 (75)45 (74)142 (87)
ECOG PS < 0.0001
 130 (13)49 (80)18 (11)
 0195 (87)12 (20)146 (89)
Timing0.69
 Synchronous194 (86)54 (89)140 (85)
 Metachronous31 (14)7 (11)24 (15)
Resected primary tumour0.16
 Yes151 (67)36 (59)115 (70)
 No74 (33)25 (41)49 (30)
Sidedness0.21
 Left159 (71)39 (64)120 (73)
 Right65 (29)22 (36)43 (26)
 Not available1 (0)0 (0)1 (1)
Nodal involvement0.10
 Yes114 (51)32 (53)82 (50)
 No53 (24)8 (13)45 (27)
 Not available58 (26)21 (34)37 (23)
Baseline CEA level0.54
 >200 ng/mL49 (22)16 (26)33 (20)
 ≤200 ng/mL128 (57)34 (56)94 (57)
 Not available48 (21)11 (18)37 (23)
Number of liver metastases 0.002
 ≥4135 (60)45 (74)90 (55)
 <469 (31)8 (13)61 (37)
 Not available21 (9)8 (13)13 (8)
Liver metastases maximum diameter0.69
 >30 mm134 (60)38 (62)96 (58)
 ≤30 mm65 (29)16 (26)49 (30)
 Not available26 (11)7 (12)19 (12)
Bilobar involvement0.22
 Yes153 (68)43 (71)110 (67)
 No63 (28)12 (20)51 (31)
 Not available9 (4)6 (9)3 (2)
Liver involvement < 0.0001
 >6 segments49 (22)26 (43)23 (14)
 ≤6 segments161 (71)26 (43)135 (82)
 Not available15 (7)9 (14)6 (4)
RAS/BRAF status0.13
 Mutated107 (48)36 (59)71 (43)
 Wild type92 (41)21 (34)71 (43)
 Not available26 (11)4 (7)22 (14)
Microsatellite status1.00
 MSI High3 (1)0 (0)3 (2)
 MSI low/MSS54 (24)9 (14)45 (27)
 Not available168 (75)52 (86)116 (71)
Induction CT0.31
 Triplet126 (56)38 (62)88 (54)
 Doublet99 (44)23 (38)76 (46)
Biological agent0.09
 Anti-EGFR57 (25)13 (21)44 (27)
 Anti-VEGF132 (59)38 (62)94 (57)
 Both11 (5)6 (10)5 (3)
 None25 (11)4 (7)21 (13)
  • *P value for χ2 and Fisher’s exact test

  • Anti-EGFR, anti-epidermal growth factor receptor; Anti-VEGF, anti-vascular endothelial growth factor; CEA, carcinoembryonic antigen;CT, chemotherapy; ECOG, Eastern Cooperative Oncology Group;MSI, microsatellite instability;MSS, microstatellite stable;PS, Performance Status.