Table 2

Human B7x expression in cancer

TumourPositive B7x expressionReferences
Lung cancer69% (128/185) and 68% in discovery and validation cohort29
Pancreatic cancer92% (33/36) in tumour samples
20% (1/5) in tumour-negative samples
20
61.9% (39/63) in pancreatic tumour samples40
HCCHBV related: HCC: 68.67% (57/83)41
93 HCC cases: mean sB7x: 49 ng/mL versus 31.66 ng/mL in healthy volunteers42
Breast cancer95.4% (165/173) primary breast cancer
97.6% (240/246) metastatic breast cancer
14
Gastric cancer25.8% (31/120)43
71% (71/100)44
Renal cancer59.1% (153/259) in tumours
81.5% in RCC endothelium versus 6.5% in normal tissue vessels
13
RCC sB7x concentration of 14.4 ng/mL versus 2.7 ng/mL in healthy volunteers13
Thyroid95.3% (61/64)45
GliomaNot reported24
Prostate cancer99% (805/814); 15% with strong intensity12
Melanoma96.5% (28/29) primary tumours
89.7% (26/29) metastatic tumours
15
Ovarian cancer100% in all 103 samples46
Urothelial cancer75.8% (42/67)47
  • HBV, Hepatitis B virus; HCC, hepatocellular carcinoma; RCC, renal cell carcinoma.